| Reliability of liver stiffness measurement in non-alcoholic fatty liver disease: the effects of body mass index. | |
| | |
MedLine Citation:
|
PMID: 21517924 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background Liver stiffness measurement (LSM) using transient elastography (TE) is used to stage fibrosis in patients with liver disease, diagnostic reliability and the factors affecting its performance in patients with non-alcoholic fatty liver disease (NAFLD) are incompletely understood. Aim To assess LSM. Methods Consecutive NAFLD patients (n = 169), assessed by liver biopsy (Kleiner score), anthropometrical, biochemical and metabolic features, underwent LSM using TE with standard M probe. Results Liver stiffness measurement was not reliable in 23 patients (14%) due to obesity. Among patients with a reliable TE, a LSM value >7.25 kPa was the best cut-off for predicting significant fibrosis at biopsy (AUC 0.794); however, this cut-off still failed to rule out F2-F4 fibrosis in 31% (false-negative rate) or rule in F3-F4 in 29% (false-positive rate). Similarly a LSM value >8.75 kPa was the best cut-off for severe fibrosis (F3-F4) (AUC 0.870), with a rate of false-negatives 24% and of false-positives 2%. Body mass index was the major determinant of these diagnostic errors in predicting significant and severe fibrosis both by overestimating or underestimating the stage of fibrosis. Conclusions In NAFLD patients, even when liver stiffness measurement is feasible, high BMI values negatively affect the diagnostic reliability. Improved performance of transient elastography could be obtained using specifically designed probes. |
| | |
Authors:
|
S Petta; V Di Marco; C Cammà; G Butera; D Cabibi; A Craxì |
Related Documents
:
|
9862594 - Determination of the minimal clinically significant difference on a patient visual anal... 7760574 - A field investigation of participant and environment effects on pharmacist-patient comm... 11720944 - Internet-based prescription of sildenafil: a 2104-patient series. 17145904 - Participation of french general practitioners in end-of-life decisions for their hospit... 21679514 - Use of narrow band imaging in evaluation of possible nasopharyngeal carcinoma. 3875464 - Lymphocytotoxic antibodies in primary biliary cirrhosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-25 |
Journal Detail:
|
Title: Alimentary pharmacology & therapeutics Volume: - ISSN: 1365-2036 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Sezione di Gastroenterologia, Di.Bi.M.I.S., University of Palermo, Palermo, Italy. Cattedra di Anatomia Patologica, University of Palermo, Palermo, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The association of coeliac disease and microscopic colitis: a large population-based study.
Next Document: The effects of food on the pharmacokinetics of mitiglinide tablets in healthy volunteers and a novel...