| Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans. | |
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MedLine Citation:
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PMID: 21348878 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Calorie restriction (CR)-induced weight loss has been shown to lower the risk of chronic disease in obese individuals. Although the mechanisms that link weight loss to disease risk reduction remain unclear, evidence suggests adipokines may play a role. What has yet to be determined, however, is the dose-response effect of body weight loss and visceral fat mass loss on adipokines. Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). The dose-response relationship between visceral fat mass loss and adipokine profile improvement will also be explored. Results from this review demonstrate that even mild weight loss induced by CR may have beneficial effects on leptin levels, but it has no clear impact on adiponectin, resistin, IL-6, IL-8, MCP-1, or RBP-4 concentrations. |
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Authors:
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Monica C Klempel; Krista A Varady |
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Publication Detail:
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Type: Journal Article Date: 2011-02-14 |
Journal Detail:
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Title: Nutrition reviews Volume: 69 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 145-54 Citation Subset: IM |
Copyright Information:
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© 2011 International Life Sciences Institute. |
Affiliation:
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Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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