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Reliability of fetal thymus measurement in prediction of 22q11.2deletion A retrospective study using 4D STIC volumes.
MedLine Citation:
PMID:  22605637     Owner:  NLM     Status:  Publisher    
Objective To evaluate the thymic-thoracic ratio (T-T ratio) method in evaluation of the thymus in the fetus. Method Database records were reviewed for cases of conotruncal and arch abnormalities found on fetal echocardiography between January 2007 and September 2011. Fetuses with aneuploidy or other genetic disorders and cases where 22q11.2 deletion status was not known, were excluded from the analysis. The T-T ratio was measured retrospectively using STIC volume datasets to image the correct view. Results Sixty-nine fetuses with relevant cardiac diagnoses were identified. Of 69, 18 (26%) had 22q11.2 deletion. The mean gestational age at diagnosis was 22 weeks. An additional 55 cases were analysed as a control group. Significant differences, as well as overlap between all three groups, were seen. The mean T-T ratio of 0.44 in our normal control group corresponded with previously published normal data. However, the T-T ratio in the group of conotruncal anomalies with a normal karyotype was also smaller than the controls, in contrast to previously published data. In addition, the T-T ratio was significantly above the normal mean, regardless of fetal karyotype, in all cases of interrupted aortic arch. Conclusion The T-T ratio method is feasible and a useful tool during detailed fetal heart assessment. However, the absolute measurement is not reliable for the prediction of 22q11.2deletion and therefore the obtained results should be analysed with caution. Fetal karyotyping should be recommended in cases where conotruncal heart abnormalities are identified, irrespective of the T-T ratio Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Roza Bataeva; Hannah Bellsham-Revell; Vita Zidere; Lindsey D Allan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-17
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Harris Birthright Centre for Fetal Medicine, King's College Hospital, London, United Kingdom.
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