Document Detail


Reliability of dipole models of epileptic spikes.
MedLine Citation:
PMID:  10402088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In order to validate dipole-modeling results, we compared dipole localizations with the distribution of intracerebral potentials occurring simultaneously with scalp EEG paroxysms. METHODS: Firstly, scalp EEGs were recorded from 11 patients. Dipole sources were estimated on averaged spikes and projected on 3D-MRIs. Secondly, stereoelectroencephalography (SEEG) was recorded from implanted electrodes with direct identification onto MRI. Simultaneously with SEEG, control scalp electrodes were pasted where spikes peaked during the first session. SEEG was averaged, triggered by the main peak of scalp spikes. RESULTS: SEEG activity during scalp spikes always involved several contacts. In 13 of 14 spikes, maximal fields occurred in neocortical regions. In 4 of 5 cases where intracerebral activity was simple, spikes could be modeled by one source. In all cases where intracerebral activity was complex, spikes had to be modeled by several sources. The main dipole source was 11 +/- 4.2 mm from the SEEG contact showing the maximal intracerebral potential. Early and late dipole localization and SEEG fields were concordant in two thirds of cases. CONCLUSION: Results indicate that in our group of patients scalp spikes reflect activity in large neocortical areas and never activity limited to mesial structures. Dipole locations and time activation were confirmed most often and were more reliable for sources representing the main negative component than for early or late sources.
Authors:
I Merlet; J Gotman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  110     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1013-28     Citation Subset:  IM    
Affiliation:
Montreal Neurological Institute, and Department of Neurology and Neurosurgery, McGill University, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / pathology,  physiopathology*
Electroencephalography
Epilepsy / pathology,  physiopathology*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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