| Reliability of Reagent Strips for Semi-quantitative Measurement of Glucosuria in a Neonatal Intensive Care Setting. | |
MedLine Citation:
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PMID: 24794329 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Glucosuria in preterm infants is often measured using a visually readable reagent strip, e.g., when monitoring total parenteral nutrition or during sepsis or when treating with corticosteroids. However, the specific circumstances in a neonatal intensive care unit (NICU), such as the use of diapers and the high temperature in incubators, could affect its reliability. OBJECTIVES: To evaluate the reliability of the semi-quantitative measurement of glucosuria under the specific circumstances of a NICU setting. METHODS: Nine hundred assessments of artificially supplemented (contrived) urine samples, intended to simulate pathological specimens, were performed under the following varying conditions: environmental temperature (21°C and 34°C); different times of contact of the urine with the diaper; and using two different methods of collecting urine from the diaper. Each reagent strip was read independently by three observers. The test strips scores were categorized as 0, 1+, 2+, 3+, or 4+ in ascending degree of glucosuria. RESULTS: Agreement was excellent under all the different conditions (temperature, weighted kappa (κw) = 0.92; method of urine collection, κw = 0.88; time, p = 0.266). Inter-observer reliability was very good (multi-rater κ = 0.81). The deviation between the different conditions was seldom larger than one category (2.9%). The reagent strip readings were concordant with the true urinary glucose concentrations in 79.0% of assessments. The discordance was never larger than one category. CONCLUSION: The reliability of the semi-quantitative measurement of glucosuria in newborn infants using reagent strips is good, even under the conditions of a NICU. Changes in the rating of reagent strips of more than one category are most likely to be beyond measurement error. |
Authors:
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Jolita Bekhof; Boudewijn J Kollen; Sjef van de Leur; Joke H Kok; Irma H L M van Straaten |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2014-4-29 |
Journal Detail:
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Title: Pediatrics and neonatology Volume: - ISSN: 1875-9572 ISO Abbreviation: Pediatr Neonatol Publication Date: 2014 Apr |
Date Detail:
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Created Date: 2014-5-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101484755 Medline TA: Pediatr Neonatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2014. Published by Elsevier B.V. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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