Document Detail


Reliability of peak exercise testing in patients with heart failure with preserved ejection fraction.
MedLine Citation:
PMID:  22981266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise intolerance is the primary symptom in patients with heart failure and preserved ejection fraction (HFpEF), a major determinant of their decreased quality of life, and an important outcome in clinical trials. Although cardiopulmonary exercise testing (CPET) provides peak and submaximal diagnostic indexes, the reliability of peak treadmill CPET in patients >55 years of age with HFpEF has not been examined. Two CPETs were performed in 52 patients with HFpEF (70 ± 7 years old). The 2 tests were separated by an average of 23 ± 13 days (median 22) and performed under identical conditions, with no intervention or change in status between visits except for initiation of a placebo run-in. A multistep protocol for patient screening, education, and quality control was used. Mean peak oxygen consumption was similar on tests 1 and 2 (14.4 ± 2.4 vs 14.3 ± 2.3 ml/kg/min). Correlation coefficients and intraclass correlations from the testing days were determined (oxygen consumption, r = 0.85, p <0.001, intraclass correlation 0.855; ventilatory anaerobic threshold, r = 0.79, p <0.001, intraclass correlation 0.790; ventilation per carbon dioxide slope, r = 0.87, p <0.001, intraclass correlation 0.864; heart rate, r = 0.94, p <0.001, intraclass correlation 0.938). These results challenge conventional wisdom that serial baseline testing is required in clinical trials with exercise-capacity outcomes. In conclusion, in women and men with HFpEF and severe physical dysfunction, key submaximal and peak ET variables exhibited good reliability and were not significantly altered by a learning effect or placebo administration.
Authors:
Jessica M Scott; Mark J Haykowsky; Joel Eggebeen; Timothy M Morgan; Peter H Brubaker; Dalane W Kitzman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2012-09-13
Journal Detail:
Title:  The American journal of cardiology     Volume:  110     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-04-16     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1809-13     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Exercise Test* / methods
Exercise Tolerance / physiology*
Female
Heart Failure / physiopathology*
Humans
Male
Oxygen Consumption / physiology*
Randomized Controlled Trials as Topic
Reproducibility of Results
Stroke Volume
Grant Support
ID/Acronym/Agency:
P30 AG021332/AG/NIA NIH HHS; P30AG21332/AG/NIA NIH HHS; R37 AG018915/AG/NIA NIH HHS; R37AG18915/AG/NIA NIH HHS
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