| Reliability of the ABC/2 Method in Determining Acute Infarct Volume. | |
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MedLine Citation:
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PMID: 21447023 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion-weighted imaging. METHODS: We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method. RESULTS: The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm(3) (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were .992 and .985 for the ABC/2 technique and planimetric method, respectively. CONCLUSIONS: ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volume. |
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Authors:
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Salvador Pedraza; Josep Puig; Gerard Blasco; Josep Daunis-I-Estadella; Imma Boada; Anton Bardera; Mar Castellanos; Joaquín Serena |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-29 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: - ISSN: 1552-6569 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 by the American Society of Neuroimaging. |
Affiliation:
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Department of Radiology (IDI), Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Universitat de Girona, Girona, Spain (SP, JP, GB); and Department of Informatics and Applied Mathematics, Universitat de Girona (JDE), Institut d'Informatica i Aplicacions, Universitat de Girona (IB, AB), Department of Neurology, Hospital Universitari Dr Josep Trueta (MC, JS), Programa de Doctorat, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain (SP). |
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