Document Detail

Reliability of the ABC/2 Method in Determining Acute Infarct Volume.
MedLine Citation:
PMID:  21447023     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE: Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion-weighted imaging. METHODS: We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method. RESULTS: The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm(3) (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were .992 and .985 for the ABC/2 technique and planimetric method, respectively. CONCLUSIONS: ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volume.
Salvador Pedraza; Josep Puig; Gerard Blasco; Josep Daunis-I-Estadella; Imma Boada; Anton Bardera; Mar Castellanos; Joaquín Serena
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-29
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  -     ISSN:  1552-6569     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 by the American Society of Neuroimaging.
Department of Radiology (IDI), Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Universitat de Girona, Girona, Spain (SP, JP, GB); and Department of Informatics and Applied Mathematics, Universitat de Girona (JDE), Institut d'Informatica i Aplicacions, Universitat de Girona (IB, AB), Department of Neurology, Hospital Universitari Dr Josep Trueta (MC, JS), Programa de Doctorat, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain (SP).
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