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Reliability of Corticomotor Excitability in Leg and Thigh Musculature at 14 and 28 Days.
MedLine Citation:
PMID:  24084315     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
CONTEXT: Alterations in corticomotor excitability are observed in a variety of patient populations, including the musculature surrounding the knee and ankle following joint injury. Active motor threshold (AMT) and motor evoked potential amplitudes (MEPs) elicited through transcranial magnetic stimulation (TMS) are outcomes measures used to assess corticomotor excitability, and have been deemed reliable in upper extremity musculature. However, there are few studies assessing the reliability of TMS measures in lower extremity musculature.
OBJECTIVE: Determine the intersession reliability of AMT and MEP amplitudes over 14 and 28 days in the quadriceps and fibularis longus (FL).
DESIGN: Descriptive Laboratory Study.
SETTING: University Laboratory PARTICIPANTS: 20 able-bodied volunteers (10M/10F; 22.35 ± 2.3 years; 1.71 ± 0.11m; 73.61 ± 16.77kg).
MAIN OUTCOME MEASURES: AMT and MEP amplitudes were evaluated at 95, 100, 105, 110, 120, 130, and 140% of AMT in the dominant and non-dominant quadriceps and FL. Interclass Correlation Coefficients (ICCs) were used to assess reliability for absolute agreement and internal consistency between baseline and two follow-up sessions at 14 and 28 days post baseline. Each ICC was fit with the best-fit straight-line or parabola in order to smooth out noise in the observations and best determine if a pattern existed in determining the most reliable MEP value.
RESULTS: All muscles yielded strong ICCs between baseline and both time points for AMT. MEPs in both the quadriceps and FL produced varying degrees of reliability, with the greatest reliability demonstrated on day 28 at 130 and 140% of AMT in the quadriceps and FL, respectively. The dominant FL muscle showed a significant pattern as TMS intensity increased MEP reliability increased.
CONCLUSION: TMS can be used to reliably identify corticomotor alterations following therapeutic interventions as well as monitor disease progression.
Authors:
Brittney A Luc; Adam S Lepley; Michael A Tevald; Phillip A Gribble; Donald B White; Brian G Pietrosimone
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-1
Journal Detail:
Title:  Journal of sport rehabilitation     Volume:  -     ISSN:  1543-3072     ISO Abbreviation:  J Sport Rehabil     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206500     Medline TA:  J Sport Rehabil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neuromuscular Research Laboratory, Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, Chapel Hill, NC.
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