Document Detail

Relevance of three-dimensional reconstructions of stain distributions for structural analysis of biomolecules.
MedLine Citation:
PMID:  51815     Owner:  NLM     Status:  MEDLINE    
The relevance of a three-dimensional model of a protein molecule is discussed in the context of artefacts which inevitably occur during the preparation and imaging process. It is emphasized that even under optimistic assumptions, there-construction of a structure complementary to a given spatial stain distribution cannot, at resolutions below 10-15 A, be regarded as being identical with the real protein structure.
W Baumeister; M Hahn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hoppe-Seyler's Zeitschrift für physiologische Chemie     Volume:  356     ISSN:  0018-4888     ISO Abbreviation:  Hoppe-Seyler's Z. Physiol. Chem.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-12-28     Completed Date:  1975-12-28     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985060R     Medline TA:  Hoppe Seylers Z Physiol Chem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1313-6     Citation Subset:  IM    
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MeSH Terms
Microscopy, Electron / methods
Models, Molecular*
Models, Structural*
Protein Binding
Protein Conformation*
Staining and Labeling
X-Ray Diffraction / methods
Reg. No./Substance:

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