| Relevance of short-term variation of B-type natriuretic peptide in patients with clinically stable heart failure. | |
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MedLine Citation:
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PMID: 19116708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In patients with clinically stable chronic heart failure, circulating B-type natriuretic peptide (BNP) levels may exhibit considerable variation over a period of a few days. The aim of this study was to evaluate the clinical impact of this phenomenon. METHODS: In 23 patients with clinically stable mild-to-moderate systolic heart failure [median (interquartile range) 72 (64-77) years, left ventricular ejection fraction 30 (27-40)%] and a history of previous hospitalization for heart failure, BNP was measured at two time points [T1 and T2, interval 5 (3-7) days] for calculation of the absolute change in BNP concentrations between T1 and T2 (DeltaBNP; irrespective of whether there was a decrease or increase). Follow-up for rehospitalization was 436 (407-458) days. RESULTS: In the group overall, DeltaBNP was 26 (9-116) pg/ml [19 (10-28)% of the value at T1]. During follow-up, 8/23 (35%) patients were rehospitalized. BNP concentrations at T1 [340 (187-533) vs. 210 (108-606) pg/ml; P = 0.33] and T2 [328 (125-491) vs. 259 (89-536) pg/ml; P = 0.51] were similar in patients who were rehospitalized and those who were not; however, DeltaBNP was higher in patients requiring rehospitalization [98 (36-186) vs. 19 (6-93) pg/ml; P = 0.04]. Patients with DeltaBNP <26 pg/ml had a longer rehospitalization-free survival than those with DeltaBNP > or = 26 pg/ml (log rank P = 0.02). Sensitivity and specificity of DeltaBNP > or = 26 pg/ml for the prediction of rehospitalization were 88% and 67% respectively. CONCLUSIONS: In this small study among patients with clinically stable heart failure, higher DeltaBNP over a period of a few days was associated with a higher likelihood of rehospitalization during follow-up. |
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Authors:
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Micha Tobias Maeder; Dietrich Hack; Hans Rickli; Hans Peter Brunner-La Rocca; Walter Riesen; Peter Ammann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Wiener klinische Wochenschrift Volume: 120 ISSN: 1613-7671 ISO Abbreviation: Wien. Klin. Wochenschr. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-12-31 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 21620870R Medline TA: Wien Klin Wochenschr Country: Austria |
Other Details:
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Languages: eng Pagination: 672-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Kantonsspital St. Gallen, Switzerland. micha.maeder@bluewin.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Heart Failure / blood*, diagnosis* Humans Male Middle Aged Natriuretic Peptide, Brain / blood* Reproducibility of Results Sensitivity and Specificity Statistics as Topic Time Factors |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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