Document Detail

Relevance of serum IgE estimation in allergic bronchial asthma with special reference to food allergy.
MedLine Citation:
PMID:  17348241     Owner:  NLM     Status:  MEDLINE    
Studies suggest the importance of serum total and specific IgE in clinical evaluation of allergic manifestations. Such studies are lacking in Indian subcontinent, though a large population suffer from bronchial asthma. Here relevance of serum total and specific IgE was investigated in asthmatics with food sensitization. A total of 216 consecutive patients (mean age 31.9 years, S.D. 11.8) were screened by various diagnostic testing. Out of 216 patients, 172 were with elevated serum total IgE (201 to > 800 IU/ml). Rice elicited marked positive skin prick test reactions (SPT) in 24 (11%) asthma patients followed by black gram 22 (10%), lentil 21 (9.7%) and citrus fruits 20 (9.2%). Serum total IgE and specific IgE showed significant correlation, p = 0.005 and p = 0.001, respectively, with positive skin tests. Blinded food challenges (DBPCFC) with rice and or black gram confirmed food sensitization in 28-37% of cases. In summary, serum total IgE of 265 IU/ml or more with marked positive SPT (4 mm or more) can serve as marker for atopy and food sensitization. Specific IgE, three times of normal controls correlates well with positive DBPCFC and offers evidence for the cases of food allergy.
Raj Kumar; Bhanu P Singh; Prakriti Srivastava; Susheela Sridhara; Naveen Arora; Shailendra N Gaur
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand     Volume:  24     ISSN:  0125-877X     ISO Abbreviation:  Asian Pac. J. Allergy Immunol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402034     Medline TA:  Asian Pac J Allergy Immunol     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India.
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MeSH Terms
Asthma / complications,  diagnosis
Biological Markers / blood
Food Hypersensitivity / blood*,  complications,  diagnosis
Immunoglobulin E / blood*
Middle Aged
Oryza sativa*
Predictive Value of Tests
Skin Tests
Reg. No./Substance:
0/Allergens; 0/Biological Markers; 37341-29-0/Immunoglobulin E

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