Document Detail


Relevance of serum ECP measurements for monitoring acute asthma in children.
MedLine Citation:
PMID:  8827939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the role of serum eosinophil cationic protein (ECP) concentration as a monitoring parameter in acute bronchial asthma, 11 children (mean age 10.2 years) were studied during an acute exacerbation of their disease. Under an appropriate anti-inflammatory therapy, FEV1 increased significantly at day 1 (p < 0.05), day 14 (p < 0.05), day 28 (p < 0.03), and day 56 (p < 0.03) compared to baseline values at referral to hospital. Serum ECP concentration decreased in the group of patients significantly at day 28 (p < 0.02) and day 56 (p < 0.04). However, considering the individual serum ECP time courses, most of the patients did not show a uniform pattern of continuously decreasing values. From our data, we conclude that measuring serum ECP concentration during acute asthma episodes in children may play a role in some patients, whereas in others--probably those without acute eosinophil inflammation--monitoring by serum ECP concentration is of limited value.
Authors:
B Niggemann; M Ertel; A Lanner; U Wahn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  33     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  1996  
Date Detail:
Created Date:  1996-11-13     Completed Date:  1996-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Affiliation:
University Children's Hospital, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Asthma / blood*,  diagnosis
Blood Proteins / analysis*
Child
Eosinophil Granule Proteins
Eosinophils / metabolism
Female
Forced Expiratory Volume
Humans
Inflammation Mediators / blood*
Male
Ribonucleases*
Time Factors
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Inflammation Mediators; EC 3.1.-/Ribonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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