| Relevance of apoptosis in influencing recovery of hibernating myocardium. | |
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MedLine Citation:
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PMID: 17127093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hibernating myocardium (HM) is viable but dysfunctional myocardium which can recover following revascularization. Myocyte necrosis is virtually absent in HM; however, cellular loss may take place by apoptosis, although this is controversial. AIM: To assess the presence of apoptosis and its relevance in HM. METHODS: During coronary artery by-pass surgery (CABG), 21 patients underwent transmural biopsy in the dysfunctional left anterior descending artery tributary area of the left ventricle (LV), with kinetic recovery at follow-up, thus fulfilling the HM criteria. All patients underwent echocardiographic follow-up at 12 months. All biopsies were evaluated by light microscopy, electron microscopy (EM), and molecular analysis. RESULTS: All biopsies were structurally altered, showing increased fibrosis and myocytes with variable size. Myocyte dedifferentiation was not detected by immunohistochemistry or EM. On stepwise linear regression, 1 year LVEF was predicted by the apoptotic index (beta=-0.973, p=0.002), the normotrophic cell percentage (beta=0.449, p=0.038), and mean fibrosis (beta=-0.412, p=0.51). CONCLUSIONS: Our biopsy study detected a wide range of morphological substrate heterogeneity in HM with degenerative features. We have demonstrated for the first time in humans that myocyte apoptosis is an important phenomenon in HM, negatively influencing LV functional recovery after CABG. |
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Authors:
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Annalisa Angelini; Giuseppe Maiolino; Giovanni La Canna; Claudio Ceconi; Fiorella Calabrese; Elena Pettenazzo; Marialuisa Valente; Ottavio Alfieri; Gaetano Thiene; Roberto Ferrari |
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Publication Detail:
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Type: Journal Article Date: 2006-11-28 |
Journal Detail:
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Title: European journal of heart failure Volume: 9 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-26 Completed Date: 2007-11-13 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 377-83 Citation Subset: IM |
Affiliation:
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Department of Pathological Anatomy, University of Padua, Via Gabelli, 61, 35121 Padova, and Department of Non-invasive Diagnostic Cardiology, San Raffaele Foundation Institute and University Hospital, Milan, Italy. annalisa.angelini@unipd.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Cardiomyopathies / physiopathology*, ultrasonography Female Fibrosis / physiopathology Heart Ventricles / physiopathology* Humans Hypertrophy, Left Ventricular / physiopathology Immunohistochemistry Male Middle Aged Muscle Cells Myocardium / cytology, pathology* Necrosis Prospective Studies Stroke Volume |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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