Document Detail

Relevance of apolipoproteins in the development of fatty liver and fatty liver-related peripartum diseases in dairy cows.
MedLine Citation:
PMID:  12014573     Owner:  NLM     Status:  MEDLINE    
Most metabolic diseases in dairy cows occur during the peripartum period and are suggested to be derived from fatty liver initially developed during the nonlactating stage. Fatty liver is induced by hepatic uptake of nonesterified fatty acids that are released in excess by adipose tissues attributable to negative energy balance. The fatty accumulation leads to impairment of lipoprotein metabolism in the liver, and the impairment in turn influences other metabolic pathways in extrahepatic tissues such as the steroid hormone production by the corpus luteum. Detailed understanding of the impaired lipoprotein metabolism is crucial for elucidation of the mechanistic bases of the development of fatty liver and fatty liver-related peripartum diseases. This review summarizes results on evaluation of lipoprotein lipid and protein concentrations and enzyme activity in cows with fatty liver and those with ketosis, left displacement of the abomasum, milk fever, downer syndrome and retained placenta. Obtained data strongly suggest that decreases in serum concentrations of apolipoprotein B-100, apolipoprotein A-I and apolipoprotein C-III, a reduction in activity of lecithin:cholesterol acyltransferase and induction of haptoglobin and serum amyloid A are intimately related to the development of fatty liver and fatty liver-related diseases. Moreover, determination of the apolipoprotein concentrations and enzyme activity during the peripartum period is useful for early diagnoses of these diseases.
Norio Katoh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  64     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-11-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  293-307     Citation Subset:  IM    
Hokkaido Research Station, National Institute of Animal Health, Sapporo, Japan.
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MeSH Terms
Abomasum / metabolism,  pathology
Apolipoproteins / metabolism*
Cattle Diseases / enzymology,  metabolism*
Fatty Liver / enzymology,  metabolism,  veterinary*
Ketosis / metabolism,  veterinary
Parturient Paresis / metabolism
Postpartum Period / metabolism
Protein Kinase C / metabolism
Reg. No./Substance:
0/Apolipoproteins; EC Kinase C

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