| Relevance of animal models for understanding mammalian copper homeostasis. | |
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MedLine Citation:
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PMID: 18779305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As a trace element, copper has a crucial role in mammalian metabolism, but it can be toxic in excess. The importance of a balanced copper homeostasis is illustrated by several copper-associated disorders in man, such as Menkes and Wilson disease, and in a wide variety of animal models (eg, mice, dogs, and sheep). Proteins involved in controlling copper metabolism have been well studied in yeast and in vitro. Recently, naturally occurring mutants and transgenic mouse models have been used to study the physiologic role of copper transporters in copper homeostasis. We discuss the most common mammalian animal models used to study copper-related diseases, evaluate what these model systems have recently shown about copper metabolism, and discuss the importance of these models for identifying specific and sensitive biomarkers associated with copper status in the near future. |
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Authors:
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Willianne I M Vonk; Cisca Wijmenga; Bart van de Sluis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 88 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-09 Completed Date: 2008-10-09 Revised Date: 2009-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 840S-5S Citation Subset: AIM; IM |
Affiliation:
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Department of Metabolic and Endocrine Disease, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cation Transport Proteins / metabolism Copper / deficiency*, metabolism*, toxicity Dog Diseases / genetics, metabolism Dogs Hepatocytes / metabolism Hepatolenticular Degeneration / genetics, metabolism Homeostasis Humans Mammals Mice Mice, Transgenic Models, Animal |
| Chemical | |
Reg. No./Substance:
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0/Cation Transport Proteins; 0/SLC31A1 protein, human; 7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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