Document Detail

Relevance of animal models for understanding mammalian copper homeostasis.
MedLine Citation:
PMID:  18779305     Owner:  NLM     Status:  MEDLINE    
As a trace element, copper has a crucial role in mammalian metabolism, but it can be toxic in excess. The importance of a balanced copper homeostasis is illustrated by several copper-associated disorders in man, such as Menkes and Wilson disease, and in a wide variety of animal models (eg, mice, dogs, and sheep). Proteins involved in controlling copper metabolism have been well studied in yeast and in vitro. Recently, naturally occurring mutants and transgenic mouse models have been used to study the physiologic role of copper transporters in copper homeostasis. We discuss the most common mammalian animal models used to study copper-related diseases, evaluate what these model systems have recently shown about copper metabolism, and discuss the importance of these models for identifying specific and sensitive biomarkers associated with copper status in the near future.
Willianne I M Vonk; Cisca Wijmenga; Bart van de Sluis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  88     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-10-09     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  840S-5S     Citation Subset:  AIM; IM    
Department of Metabolic and Endocrine Disease, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
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MeSH Terms
Cation Transport Proteins / metabolism
Copper / deficiency*,  metabolism*,  toxicity
Dog Diseases / genetics,  metabolism
Hepatocytes / metabolism
Hepatolenticular Degeneration / genetics,  metabolism
Mice, Transgenic
Models, Animal
Reg. No./Substance:
0/Cation Transport Proteins; 0/SLC31A1 protein, human; 7440-50-8/Copper

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