| Relevance of VEGF and nephrin expression in glomerular diseases. | |
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MedLine Citation:
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PMID: 21808734 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The glomerular filtration barrier is affected in a large number of acquired and inherited diseases resulting in extensive leakage of plasma albumin and larger proteins, leading to nephrotic syndrome and end-stage renal disease. Unfortunately, the molecular mechanisms governing the development of the nephrotic syndrome remain poorly understood. Here, I give an overview of recent investigations that have focused on characterizing the interrelationships between the slit diaphragm components and podocytes-secreted VEGF, which have a significant role for maintaining the normal podocyte structure and the integrity of the filtering barrier. |
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Authors:
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Claudia A Bertuccio |
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Publication Detail:
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Type: Journal Article Date: 2011-07-26 |
Journal Detail:
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Title: Journal of signal transduction Volume: 2011 ISSN: 2090-1747 ISO Abbreviation: J Signal Transduct Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101536934 Medline TA: J Signal Transduct Country: Egypt |
Other Details:
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Languages: eng Pagination: 718609 Citation Subset: - |
Affiliation:
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Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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