| Relevance of T2 signal changes in the assessment of progression of glioblastoma according to the Response Assessment in Neurooncology criteria. | |
| | |
MedLine Citation:
|
PMID: 22146386 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: According to the Response Assessment in Neurooncology (RANO) criteria, significant nonenhancing signal increase in T2-weighted images qualifies for progression in high-grade glioma (T2-progress), even if there is no change in the contrast-enhancing tumor portion. The purpose of this retrospective study was to assess the frequency of isolated T2-progress and its predictive value on subsequent T1-progress, as determined by a T2 signal increase of 15% or 25%, respectively. The frequency of T2-progress was correlated with antiangiogenic therapy. Patients and Methods: MRI follow-up examinations (n = 777) of 144 patients with histologically proven glioblastoma were assessed for contrast-enhanced T1 and T2-weighted images. Examinations were classified as T1-progress, T2-progress with 15% or 25% T2-signal increase, stable disease, or partial or complete response. Results: Thirty-five examinations revealed exclusive T2-progress using the 15% criterion, and only 2 examinations qualified for the 25% criterion; 61.8% of the scans presenting T2-progress and 31.5% of the scans presenting stable disease revealed T1-progress in the next follow-up examination. The χ(2) test showed a highly significant correlation (P < .001) between T2-progress, with the 15% criterion and subsequent T1-progress. No correlation between antiangiogenic therapy and T2-progress was shown. Conclusion: Tumor progression, as determined by both contrast-enhanced T1 and T2 sequences is more frequently diagnosed than when considering only contrast-enhanced T1 sequences. Definition of T2-progress by a 15% T2-signal increase criterion is superior to a 25% criterion. The missing correlation of T2-progress and antiangiogenic therapy supports the hypothesis of T2-progress as part of the natural course of the tumor disease. |
| | |
Authors:
|
Alexander Radbruch; Kira Lutz; Benedikt Wiestler; Philipp Bäumer; Sabine Heiland; Wolfgang Wick; Martin Bendszus |
Related Documents
:
|
10778466 - Helical ct and ureteral colic. 8615256 - Helical (spiral) ct angiography for identification of crossing vessels at the ureterope... 17621616 - Ureteric colic: new trends in diagnosis and treatment. 14744346 - Correlation of ureteral stone measurements by ct and plain film radiography: utility of... 8550776 - The accuracy of parathyroid gland localization in primary hyperparathyroidism using ses... 11232076 - Imaging of osteochondral lesions of the talus. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
|
Title: Neuro-oncology Volume: - ISSN: 1523-5866 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100887420 Medline TA: Neuro Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Neuroradiology (A.R., K.L., P.B., S.H., M.B.); Department of Neuro-oncology, University of Heidelberg Medical Center, Heidelberg, Germany (B.W., W.W.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An electron paramagnetic resonance study of the tetragonally distorted [Formula: see text] ion in [F...
Next Document: Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positi...