Document Detail


Relevance of ICAM-1 to alcoholic liver cirrhosis.
MedLine Citation:
PMID:  8856795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An elevated serum concentration of soluble intercellular adhesion molecule-1 (sICAM-1) was observed in patients with alcoholic liver cirrhosis in strong correlation with the current activity of the liver disease and the history of alcohol consumption. Circulating ICAM-1 levels were significantly elevated in the sera of all of 25 patients (1,400 +/- 850 ng/ml) compared with normal healthy subjects. The highest levels of sICAM-1 (2,650 +/- 560 ng/ml) were measured in those patients who suffered from superimposed acute alcoholic hepatitis (SAH). Regularly drinking cirrhotic patients without SAH also exhibited significantly higher results than those who had stopped drinking. The serum ICAM-1 concentration showed a negative correlation with the duration of abstinence. No elevated sICAM-1 was found in ascitic fluid of cirrhotic patients, which tends to discount a significant intraperitoneal production of this molecule. flow cytometric analysis revealed an increased expression of ICAM-1 molecules on peripheral blood monocytes of cirrhotic patients. Proliferating bile ducts and parenchymal cells of cirrhotic livers displayed a positive ICAM-1 immunohistochemical reaction in 3 autopsy cases. It is concluded that the elevated levels of sICAM-1 in the serum of patients with alcoholic liver diseases may provide useful diagnostic or prognostic information. However, determination of the exact source of circulating ICAM-1 in patients with alcoholic cirrhosis still demands further investigations.
Authors:
Y Mándi; I Nagy; L Krenács; I Ocsovszky; Z Nagy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathobiology : journal of immunopathology, molecular and cellular biology     Volume:  64     ISSN:  1015-2008     ISO Abbreviation:  Pathobiology     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-03     Completed Date:  1997-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007504     Medline TA:  Pathobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adult
Ascitic Fluid / chemistry
Female
Humans
Immunohistochemistry
Intercellular Adhesion Molecule-1 / biosynthesis*,  blood*
Liver / immunology,  metabolism
Liver Cirrhosis, Alcoholic / metabolism*
Male
Middle Aged
Monocytes / immunology,  metabolism
Chemical
Reg. No./Substance:
126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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