Document Detail


Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine.
MedLine Citation:
PMID:  23203919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial organ remodeling is a major contributing factor to worldwide death and disease, costing healthcare systems billions of dollars every year. Despite this, most fundamental epithelial organ research fails to produce new therapies and mortality rates for epithelial organ diseases remain unacceptably high. In large part, this failure in translating basic epithelial research into clinical therapy is due to a lack of relevance in existing preclinical models. To correct this, new models are required that improve preclinical target identification, pharmacological lead validation, and compound optimization. In this review, we discuss the relevance of human stem cell-derived, three-dimensional organoid models for addressing each of these challenges. We highlight the advantages of stem cell-derived organoid models over existing culture systems, discuss recent advances in epithelial tissue-specific organoids, and present a paradigm for using organoid models in human translational medicine.
Authors:
Robert E Hynds; Adam Giangreco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  31     ISSN:  1549-4918     ISO Abbreviation:  Stem Cells     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2014-01-07     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  United States    
Other Details:
Languages:  eng     Pagination:  417-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 AlphaMed Press.
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation / physiology
Humans
Models, Biological
Organoids / cytology*,  transplantation*
Stem Cell Transplantation / methods*
Stem Cells / cytology*
Translational Medical Research / methods*
Grant Support
ID/Acronym/Agency:
260290//European Research Council; //Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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