Document Detail


Relevance of Dopamine D(2)/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders.
MedLine Citation:
PMID:  22335510     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS(1)/D(2) receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration. The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D2 or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.
Authors:
S Tanganelli; T Antonelli; M C Tomasini; S Beggiato; K Fuxe; L Ferraro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  19     ISSN:  1875-533X     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  304-16     Citation Subset:  IM    
Affiliation:
Department of Clinical and Experimental Medicine, Pharmacology Section, Via Fossato di Mortara 17-19, 44100, Ferrara, Italy. frl@unife.it.
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