|Relegating malaria resurgences to history.|
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|PMID: 22531295 Owner: NLM Status: MEDLINE|
|Progress in malaria control over the past decade has been striking, with malaria mortality rates falling by approximately one quarter globally and more than a third in the World Health Organization African Region. In the accompanying paper, Cohen et al. demonstrate the potential fragility of these gains, comprehensively describing malaria resurgences that have occurred over the past 80 or so years. They found that the vast majority of resurgences were due, at least in part, to the weakening of malaria control programmes; resource constraints were the most commonly identified factor. Their findings are timely and compelling, demonstrating that global efforts will be wasted if the required resources are not secured to achieve and maintain universal access to life-saving malaria prevention and control tools. The greatest threats to current malaria control efforts are not biological, but financial. The increases in funding for malaria over the past decade, while impressive, still fall far short of the nearly $6 billion dollars required annually. Domestic spending by endemic country governments on malaria specifically, and health more generally, could go a long way towards filling the projected funding gap. However, external funding is also essential, and the global community needs to work together to ensure full funding of the Global Fund to Fight AIDS, Tuberculosis, and Malaria, which has been the single largest source of malaria funding over the past decade. This year, on April 25th, World Malaria Day will be celebrated with the theme Sustain Gains, Save Lives: Invest in Malaria. The review by Cohen et al. suggests one possible future if such investment is not made. However, with sufficient support, malaria resurgences can be relegated to history.|
|Robert D Newman|
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|Type: Comment; Journal Article Date: 2012-04-24|
|Title: Malaria journal Volume: 11 ISSN: 1475-2875 ISO Abbreviation: Malar. J. Publication Date: 2012|
|Created Date: 2012-10-05 Completed Date: 2013-01-30 Revised Date: 2013-06-25|
Medline Journal Info:
|Nlm Unique ID: 101139802 Medline TA: Malar J Country: England|
|Languages: eng Pagination: 123 Citation Subset: IM|
|Global Malaria Programme, World Health Organization, 20, Avenue Appia, CH-1211 Geneva, 27, Switzerland. email@example.com|
|APA/MLA Format Download EndNote Download BibTex|
Communicable Disease Control
Communicable Diseases, Emerging / epidemiology*
Malaria / epidemiology*
|Malar J. 2012;11:122
Journal ID (nlm-ta): Malar J
Journal ID (iso-abbrev): Malar. J
Publisher: BioMed Central
Copyright ©2012 Newman; licensee BioMed Central Ltd.
Received Day: 13 Month: 4 Year: 2012
Accepted Day: 16 Month: 4 Year: 2012
collection publication date: Year: 2012
Electronic publication date: Day: 24 Month: 4 Year: 2012
Volume: 11First Page: 123 Last Page: 123
Publisher Id: 1475-2875-11-123
PubMed Id: 22531295
|Relegating malaria resurgences to history|
|Robert D Newman1||Email: firstname.lastname@example.org|
1Global Malaria Programme, World Health Organization, 20, Avenue Appia, CH-1211, Geneva, 27, Switzerland
Over the past decade, malaria has been reinstated as a priority for global health investment. International funding commitments for malaria control have risen from under $100 million in 2003 to more than $2 billion in 2011. These resources have allowed for the scale-up of proven malaria control interventions, including long-lasting insecticidal nets (LLINs), indoor residual spraying, diagnostic testing, and treatment with highly efficacious artemisinin-based combination therapy. As an example, more than 290 million LLINs were distributed in sub-Saharan Africa between 2008 and the end of 2010 .
Concurrent with the dramatic increases in access to malaria control interventions, malaria cases have fallen by more than 50% in 43 countries (eight of them in Africa) over the past decade; another eight countries have registered declines of more than 25% . While many of these declines occurred in countries with already low malaria transmission, some have occurred in settings with moderate-to-high transmission. Over this same time period, malaria mortality rates have fallen by approximately one quarter globally and more than a third in the WHO African Region .
While the progress in malaria control has been striking, it is frequently described as fragile. In the accompanying paper, Cohen et al. demonstrate just how true this is, comprehensively describing malaria resurgences that have occurred over the past 80 or so years . They found that the vast majority (more than 90%) of resurgences were due, at least in part, to the weakening of malaria control programmes; resource constraints were the most commonly identified factor. Less than one third of resurgences were associated with drug or insecticide resistance.
Their findings are timely and compelling. While addressing Plasmodium resistance to anti-malarial medicines and Anopheles resistance to insecticides are urgent priorities requiring concerted global action [3,4], such efforts will be wasted if the required resources are not secured to achieve and maintain universal access to life-saving malaria prevention and control tools. The greatest threats to current malaria control efforts are not biological, but financial.
The increases in funding for malaria over the past decade, while impressive, still fall far short of the nearly $6 billion dollars required annually to ensure universal access to malaria prevention and control . Despite stable and significant funding from the United States through the Presidents Malaria Initiative, and recent substantial commitments from the UK through the Department for International Development, the financial projections for the coming years are concerning. Based on current information, resources available for global malaria efforts are projected to remain relatively stable in 20122013, and then decline through 2015 .
That downward trend can, however, be reversed. First, increased domestic spending by endemic country governments on malaria specifically, and health more generally, could go a long way towards filling the projected funding gap. If just 1% of total domestic spending were made available for malaria control, 75 of the 99 countries with ongoing malaria transmission could raise enough to provide each person at risk with access to an ITN . Second, the global community needs to work together to ensure full funding of the Global Fund to Fight AIDS, Tuberculosis, and Malaria. The Global Fund has been the single largest source of malaria funding over the past decade. The failure to fully replenish the Fund places a decade of progress at major risk. The cancellation of Round 11, and the limited pool of funding available through the Transitional Funding Mechanism, risk causing the very sort of service interruptions that Cohen at al have identified as being a primary factor in documented malaria resurgences.
In the case of malaria, the fact that the Global Fund has not categorized malaria prevention and control interventions as being eligible for Continuity of Services funding, as is the case for anti-retroviral and anti-tuberculosis medicines, medicines to prevent mother to child transmission of HIV, and opioid substitution therapy, only heightens the risk of reversing the gains in malaria control following service interruptions . The failure to replace an LLIN before it is worn out places individual lives at risk, especially as continuous protection against malaria diminishes the acquisition of partial immunity. The failure to replace a cohort of LLINs in a timely manner places entire populations at risk of dramatic resurgences in malaria transmission, as demonstrated by Cohen et al..
But such population-level reversals are not inevitable. What Cohen et al. discuss only briefly are the countries that have successfully controlled or eliminated malaria and then maintained those achievements. Malaysia, Thailand, and Viet Nam, for example, have substantially reduced malaria cases and deaths since the early 1990s by intensifying and maintaining preventive efforts and ensuring wide availability of anti-malarial medicines. Reunion and Singapore have been able to maintain their malaria free status despite a continual risk of importation . This sort of durable progress is an integral part not only of reaching ambitious global malaria targets, but of reaching the health-related Millennium Development Goals by 2015.
These successes demonstrate that the 43 countries where malaria cases have fallen by more than half over the past decade are not doomed to resurgence: malaria control does work, and the gains can be maintained. Such progress need not be ephemeral. Accomplishing this, however, requires continued political and financial commitment not only on the part of donors, but by endemic countries themselves.
This year, on April 25th, World Malaria Day will be celebrated with the theme Sustain Gains, Save Lives: Invest in Malaria. The review by Cohen et al. suggests one possible future if such investment is not made. However, with sufficient support, malaria resurgences can be relegated to history.
The author declares that he has no competing interests.
The views expressed in this publication are those of the author and do not necessarily represent the decisions, policy, or views of the World Health Organization.
|WHOWorld Malaria Report 2011Year: 2011World Health Organization, Geneva|
|Cohen JM,Smith DL,Cotter C,Ward A,Yamey G,Sabot OJ,Moonen B,Malaria resurgence: a systematic review and assessment of its causesMalar JYear: 20121112210.1186/1475-2875-11-12222531245|
|WHOGlobal Plan for Artemisinin Resistance ContainmentYear: 2011World Health Organization, Geneva|
|WHOGlobal Plan for Insecticide Resistance Management in malaria vectorsWorld Health Organization, Geneva In Press.|
|RBMGlobal Malaria Action PlanYear: 2008Roll Back Malaria Partnership, Geneva|
|The Global Fund to Fight AIDS, Tuberculosis, and MalariaOperational Policy Note: Continuity of Services July 2011 (http://www.theglobalfund.org/documents/core/manuals/Core_ContinuityOfServices_Note_en).|
Keywords: Malaria, Resurgence, Financing.
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