Document Detail

Released intranasal eosinophilic major basic protein as a diagnostic marker for polypoid chronic rhinosinusitis.
MedLine Citation:
PMID:  20723776     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the hypothesis that eosinophil major basic protein is released in high concentrations in the nasal mucus of patients with polypoid chronic rhinosinusitis. STUDY DESIGN: Single center, open, prospective trial. SETTING: Medical University of Graz, Austria. SUBJECTS AND METHODS: Patients with polypoid chronic rhinosinusitis (n = 23) were compared to three different control groups: patients with chronic rhinosinusitis-like symptoms but without general mucosal thickening, patients who underwent functional endoscopic sinus surgery for reasons other than chronic rhinosinusitis, and patients without sinus disease (total n = 21). Mucus was harvested from each patient using a standardized technique and analyzed for eosinophil major basic protein with an enzyme-linked immunosorbent assay. RESULTS: In the patient group with polypoid chronic rhinosinusitis, 20 of 23 (87%) were positive for eosinophil major basic protein. In contrast, only one control patient was positive, whereas the remainder had no detectable amount of eosinophil major basic protein in the mucus (P < 0.001 vs chronic rhinosinusitis). CONCLUSION: Toxic eosinophil major basic protein levels are elevated in polypoid chronic rhinosinusitis patients compared to control groups that have similar clinical presentations but upon closer examination turn out not to have chronic rhinosinusitis. In the future, the detection of eosinophil major basic protein in nasal mucus may become a sensitive and specific marker for chronic rhinosinusitis and a helpful diagnostic tool.
Christoph Schmid; Walter Habermann; Hannes Braun; Markus Gugatschka; Brad S Oriel; Janel A Smietana; Heinz Stammberger
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  143     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-20     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  386-91     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
Department of Otorhinolaryngology-Head and Neck Surgery, Medical University of Graz, Graz, Austria.
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MeSH Terms
Biological Markers / metabolism
Chronic Disease
Cohort Studies
Diagnosis, Differential
Eosinophil Major Basic Protein / metabolism*
Middle Aged
Mucus / metabolism*
Nasal Polyps / diagnosis*,  metabolism
Predictive Value of Tests
Rhinitis / diagnosis*,  metabolism
Sinusitis / diagnosis*,  metabolism
Young Adult
Reg. No./Substance:
0/Biological Markers; EC 3.1.27.-/Eosinophil Major Basic Protein

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