Document Detail

Release of vasoactive intestinal polypeptide anally of a local distension of the feline small intestine.
MedLine Citation:
PMID:  3630722     Owner:  NLM     Status:  MEDLINE    
The peristaltic reflex is elicited by a local distension of the intestine and consists of an ascending contraction and a descending inhibition of the smooth muscle layer. The transmitter mediating the inhibition of the smooth muscle cells is not known but vasoactive intestinal polypeptide (VIP) has, among others, been proposed to mediate the descending inhibition of a distension. An in vivo preparation of a segment of the feline intestine was designed to allow collection of the venous effluent and determination of the VIP release orally and anally of a distension. The release of VIP rose significantly more on the anal side of the intestinal distension, and so did the blood flow. Division of the myenteric plexus prevented the asymmetry of the VIP release to a large extent. These effects of distension on the release of VIP are consistent with the hypothesis that VIP mediates the descending inhibition of the peristaltic reflex.
A Sjöqvist; J Fahrenkrug
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  130     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-29     Completed Date:  1987-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  433-8     Citation Subset:  IM    
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MeSH Terms
Intestine, Small / blood supply,  physiology,  secretion*
Vasoactive Intestinal Peptide / secretion*
Reg. No./Substance:
37221-79-7/Vasoactive Intestinal Peptide

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