| Release of testosterone from an osmotic pump tablet utilizing (SBE)7m-beta-cyclodextrin as both a solubilizing and an osmotic pump agent. | |
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MedLine Citation:
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PMID: 10021487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A controlled porosity osmotic pump system for poorly water soluble drugs has been developed using sulfobutyl ether-beta-cyclodextrin sodium salt, (SBE)7m-beta-CD, which can act as both a solubilizing and an osmotic agent. The release of testosterone, a poorly water soluble drug (0.039 mg/ml at 37 degrees C), was evaluated using a new model device. The effect of (SBE)7m-beta-CD as the solubilizing and osmotic pump agent was compared with hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a neutral cyclodextrin, and a sugar mixture (osmotic agent only). Testosterone release from the device was significantly faster with (SBE)7m-beta-CD than with HP-beta-CD or the sugar mixture. The solubility of testosterone in the device increased to 76.7 mg/ml through complexation with (SBE)7m-beta-CD in the imbibed water. It appears that testosterone release from the device in the presence of (SBE)7m-beta-CD was mainly due to osmotic pumping while for HP-beta-CD the major contribution appears to be due to diffusion. In the case of the sugar mixture, testosterone was poorly released, presumably due to the absence of a solubilizer. Therefore, it was concluded that (SBE)7m-beta-CD provides novel properties for the development of controlled- porosity osmotic pump tablets for poor solubility drugs. |
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Authors:
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K Okimoto; R A Rajewski; V J Stella |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 58 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-04 Completed Date: 1999-05-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 29-38 Citation Subset: IM |
Affiliation:
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Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Carbohydrate Sequence Cyclodextrins / chemistry* Delayed-Action Preparations Diffusion Kinetics Membranes, Artificial Molecular Sequence Data Osmotic Pressure Solubility Tablets Testosterone / administration & dosage*, chemistry beta-Cyclodextrins* |
| Chemical | |
Reg. No./Substance:
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0/Cyclodextrins; 0/Delayed-Action Preparations; 0/Membranes, Artificial; 0/SBE4-beta-cyclodextrin; 0/Tablets; 0/beta-Cyclodextrins; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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