| Release of superoxide dismutase activity from human umbilical veins by heparin. | |
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MedLine Citation:
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PMID: 10685235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study evaluated superoxide dismutase activity released from human umbilical veins incubated with different doses of heparin and examined at different time points. STUDY DESIGN: Umbilical veins of fresh cords from full term babies were incubated with 175 or 1 U/ml of heparin at one end while the other end was incubated without heparin as control. Specimens were obtained at 10 minutes and 24 hours (high-dose) or at 10 minutes and 60 minutes (low-dose). Superoxide dismutase activity was measured by the cytochrome c method. Results were analyzed using Student's paired t test. RESULTS: A time-dependent release of superoxide dismutase activity into the buffer was observed in both heparin specimens as well as in control specimens. The difference in release in the presence of heparin was of statistical significance, compared with the controls. CONCLUSION: Because heparin is routinely used as an anticoagulant to maintain the patency of umbilical catheters, we conclude that this usage may alter a newborn's response to oxygen free radical damage by changes in superoxide dismutase activity. |
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Authors:
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Z A Gill; A M Castillo; L Rosenfeld; H S Dweck |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 19 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 1999 Jun |
Date Detail:
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Created Date: 2000-03-13 Completed Date: 2000-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 260-3 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, New York Medical College, Westchester Medical Center, Valhalla 10595, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Heparin
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administration & dosage* Humans Reperfusion Injury / physiopathology Superoxide Dismutase / secretion* Umbilical Veins / metabolism* Vascular Patency |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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