Document Detail

Release of superoxide dismutase activity from human umbilical veins by heparin.
MedLine Citation:
PMID:  10685235     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study evaluated superoxide dismutase activity released from human umbilical veins incubated with different doses of heparin and examined at different time points. STUDY DESIGN: Umbilical veins of fresh cords from full term babies were incubated with 175 or 1 U/ml of heparin at one end while the other end was incubated without heparin as control. Specimens were obtained at 10 minutes and 24 hours (high-dose) or at 10 minutes and 60 minutes (low-dose). Superoxide dismutase activity was measured by the cytochrome c method. Results were analyzed using Student's paired t test. RESULTS: A time-dependent release of superoxide dismutase activity into the buffer was observed in both heparin specimens as well as in control specimens. The difference in release in the presence of heparin was of statistical significance, compared with the controls. CONCLUSION: Because heparin is routinely used as an anticoagulant to maintain the patency of umbilical catheters, we conclude that this usage may alter a newborn's response to oxygen free radical damage by changes in superoxide dismutase activity.
Z A Gill; A M Castillo; L Rosenfeld; H S Dweck
Related Documents :
7759605 - Complement depletion affects demyelination and inflammation in experimental allergic ne...
17359305 - Welfare consequences of mulesing of sheep.
3889155 - Inhibition of anti-dnp antibody formation by high doses of dnp-polyacrylamide molecules...
15085465 - Pharmacodynamic considerations in the selection of dosage of tinzaparin for various ind...
4006125 - Periodic procainamide for paroxysmal tachycardia.
15359505 - Effects of the anticholinesterase drug tacrine on the development of ptz kindling and o...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  19     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-03-13     Completed Date:  2000-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  260-3     Citation Subset:  IM    
Department of Pediatrics, New York Medical College, Westchester Medical Center, Valhalla 10595, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Heparin / administration & dosage*
Reperfusion Injury / physiopathology
Superoxide Dismutase / secretion*
Umbilical Veins / metabolism*
Vascular Patency
Reg. No./Substance:
9005-49-6/Heparin; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fetal erythropoietin levels in growth-restricted and appropriately grown neonates with and without a...
Next Document:  Preterm infant thermal care: differing thermal environments produced by air versus skin servo-contro...