Document Detail

Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve.
MedLine Citation:
PMID:  2408705     Owner:  NLM     Status:  MEDLINE    
Substance P is a putative mediator of neurogenic inflammation, where it is postulated to be released from nerve terminals in the skin in response to noxious and electrical stimulation. To demonstrate release of substance P from cutaneous nerve terminals a blister model has been established. Electrical stimulation of the sciatic nerve for 20 min at 50 V, 15 Hz, 0.5 ms, resulted in a significant increase in substance P-like immunoreactivity (SPLI) in blister fluid, which was abolished after neonatal pretreatment of rats with capsaicin. There was no increase of SPLI, following stimulation of the sciatic nerve at 4 V. There was a corresponding decrease in skin SPLI following nerve stimulation at 50 V. Characterization of blister fluid SPLI after stimulation at 50 V demonstrated a peak of immunoreactivity, which co-eluted with synthetic substance P and SPLI from rat skin. These results confirm the hypothesis that electrical stimulation results in release of substance P from nerve terminals in the skin, and therefore fulfils an important criterion of its role as a mediator of neurogenic inflammation.
D M White; R D Helme
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  336     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-20     Completed Date:  1985-08-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal
Electric Stimulation
Inflammation / metabolism*
Nerve Endings / secretion
Peripheral Nerves / secretion*
Rats, Inbred Strains
Substance P / secretion*
Reg. No./Substance:
33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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