Document Detail


Release of soluble tumour necrosis factor alpha receptors during and after paediatric cardiopulmonary bypass. Correlation with haemodynamic and clinical variables.
MedLine Citation:
PMID:  9050754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The release of cytokines during cardiopulmonary bypass (CPB) may contribute to haemodynamic alternations encountered after open heart surgery. Regulatory mechanisms exist and include soluble cytokine receptors. We have measured blood levels of tumour necrosis factor (TNF) and its soluble receptor (TNFsr) during and after open heart surgery in children. Correlation analysis to haemodynamic and clinical variables was performed. Using immunoassays the authors registered a significant increase in plasma levels of TNFsr with peak levels 2 h post-operatively at a level of 1702 +/- 170 pg/ml. The concentration of TNFsr remained significantly elevated until 48 h postoperatively but TNF was not significantly elevated. An inverse correlation existed between peak TNFsr and mean arterial pressure (rho = -0.827, P < 0.05), between TNFsr and cardiac index (rho = -0.8, P < 0.05), between TNFsr and left ventricular stroke work index (rho = -0.983, P < 0.01), between TNFsr and weight (rho = -0.85, P < 0.05) and between TNFsr and body surface area (rho = -0.867, P < 0.05). The authors demonstrate that the smallest children experienced the highest TNFsr concentration post-operatively. Furthermore cardiac performance, expressed as cardiac index and left ventricular stroke work index, correlated inversely to peak TNFsr level post-operatively.
Authors:
K Saatvedt; H Lindberg; S Michelsen; T Pedersen; E Seem; O Geiran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytokine     Volume:  8     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  944-8     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Rikshospitalet, Oslo, Norway.
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MeSH Terms
Descriptor/Qualifier:
Cardiopulmonary Bypass*
Child
Hemodynamics
Humans
Pediatrics
Receptors, Tumor Necrosis Factor / metabolism*
Solubility
Tumor Necrosis Factor-alpha / metabolism*
Chemical
Reg. No./Substance:
0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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