Document Detail

Release of prostaglandins from the passively distended wall of guinea pig small intestine.
MedLine Citation:
PMID:  7241858     Owner:  NLM     Status:  MEDLINE    
The effects of the radial distension of the intestinal wall and the increased intraluminal pressure on the liberation of prostaglandins (PGs) were studied with the isolated guinea pig ileum. Both procedures were accompanied by an increased output of a prostaglandin-like substance and the release was proportional to the degree of distension or intraluminal pressure. Thin-layer chromatography coupled with bioassay suggested that this substance may be a mixture of PGF2 alpha, PGE2 and PGE1. The existence of the former two types of PGs were prominent. The distension-induced release of PG-like substance was assumed to be not mediated by nerve excitation since tetrodotoxin failed to inhibit the release. The increased output of the PG-like substance was not maintained after distension of the intestinal wall, despite continued application of stimulus, indicating that actual tissue deformation is an essential condition leading to increased PG output. It is concluded that distension of the intestinal wall to its circumferential direction is an appropriate stimulus for the release of PG-like substance from the small intestine. The present results favor the view that prostaglandins may participate in the peristaltic activity.
O Yagasaki; M Takai; I Yanagiya
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  30     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  583-60     Citation Subset:  IM    
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MeSH Terms
Guinea Pigs
Intestine, Small / metabolism*
Muscle Relaxation
Prostaglandins / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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