Document Detail

Release of prostaglandins during reversal of one-kidney, but not two-kidney, one clip hypertension in the rat.
MedLine Citation:
PMID:  6570485     Owner:  NLM     Status:  MEDLINE    
Changes in systolic blood pressure and urinary excretion of PGE2 and 6-keto PGF1 alpha 24 h after removing the renal artery clip were compared in one-kidney and two-kidney, one clip Goldblatt hypertension in the rat. Unclipping the one-kidney rat returned blood pressure to normotensive levels within 24 h and was associated with a substantial increase in urinary PGE2 and 6-keto PGF1 alpha. Although hypertension was also completely reversed in the two-kidney model there was no significant change in urinary prostaglandin excretion. Prior treatment with indomethacin (6.0 mg/kg) markedly reduced urinary prostaglandins after clip removal in both forms of hypertension but attenuated the fall in blood pressure in the one-kidney model only. There were no significant changes in urinary kallikrein activity following unclipping. It is suggested that in the one-kidney, one clip rat prostaglandins are released as the result of exposing the unclipped kidney to elevated arterial pressure and that these contribute to the subsequent fall in blood pressure.
R Vandongen; J O'Dwyer; A Barden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  1     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Hypertension, Renal / physiopathology*
Indomethacin / pharmacology
Kallikreins / urine
Prostaglandins / secretion*
Rats, Inbred Strains
Reg. No./Substance:
0/Prostaglandins; 53-86-1/Indomethacin; EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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