| Release of prostaglandin from the rabbit isolated heart following vagal nerve stimulation or acetylcholine infusion. | |
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MedLine Citation:
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PMID: 4458847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Rabbit hearts were perfused by the Langendorff technique. The lipid fraction in the perfusate from the heart was isolated and analysed for prostaglandins by thin layer chromatography and quantitative assay on the rat isolated stomach strip.2 Infusion of acetylcholine at a rate of 8 mug/min significantly increased the outflow of prostaglandins from the heart, from 1.8 to 6.2 ng/minute.3 Addition of atropine (1 mug/ml) to the perfusing medium completely abolished not only the mechanical response but also the increase in outflow of prostaglandins caused by infusion of acetylcholine.4 Bilateral stimulation of the parasympathetic nerves to the heart at 5 Hz also significantly increased the outflow of prostaglandins from the organ from 5.2 to 8.3 ng/minute.5 Both prostaglandin E(1) and E(2) were isolated from the lipid fraction of the perfusate.6 The role of prostaglandins in relation to autonomic neurotransmission in the heart is discussed. |
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Authors:
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M Junstad; A Wennmalm |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 52 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1974 Nov |
Date Detail:
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Created Date: 1975-07-28 Completed Date: 1975-07-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 375-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology* Animals Electric Stimulation Heart / drug effects Male Myocardium / metabolism* Perfusion Prostaglandins / metabolism* Rabbits Time Factors Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 51-84-3/Acetylcholine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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