| Release of prostaglandin D2 and histamine in a case of localized heat urticaria, and effect of treatments. | |
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MedLine Citation:
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PMID: 2432916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of localized heat urticaria in a 70-year-old woman is reported. Increased plasma levels of prostaglandin D2 and blood histamine after heat challenge indicate a role for mast cell degranulation in the pathophysiology of the syndrome. Treatment with astemizole increased the temperature threshold to wealing, but not to itch or erythema. The patient was partially desensitized by repeated exposure to heat and this was further improved by indomethacin. After treatment there was no increase in plasma prostaglandin D2 on challenge. No evidence was found for the activation of the alternative complement pathway. |
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Authors:
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O Koro; J S Dover; D M Francis; A Kobza Black; R W Kelly; R M Barr; M W Greaves |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The British journal of dermatology Volume: 115 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-03-11 Completed Date: 1987-03-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 721-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Histamine / blood* Histamine Release Hot Temperature / adverse effects* Humans Prostaglandin D2 Prostaglandins D / blood* Urticaria / blood*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins D; 41598-07-6/Prostaglandin D2; 51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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