| Release profile of insulin entrapped on mesoporous materials by freeze-thaw method. | |
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MedLine Citation:
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PMID: 19931606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adsorption profiles of insulin on porous materials and release profiles of insulin entrapped on folded-sheet mesoporous silica (FSM) were studied. Three types of FSM with different pore sizes (3.0, 6.1, and 9.2 nm) were used as candidates. A simple technique of repeated freezing and thawing resulted in effective adsorption of insulin on mesoporous structures. The amount of adsorbed insulin, estimated by protein assay, increased with an increase in the pore sizes of FSM used. Nitrogen sorption analysis showed that the specific surface area and pore volume decreased according to the insulin adsorption. On the release profile of insulin, the smallest pore size of FSM (3.0) was found to be a suitable material for a fast release of insulin, whereas the medium-pore FSM (6.1) held the insulin inside the pores for a longer time. Consequently, the desired release of insulin could be achieved by selecting the appropriate pore size of FSM. |
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Authors:
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Yuichi Tozuka; Eri Sugiyama; Hirofumi Takeuchi |
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Publication Detail:
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Type: Journal Article Date: 2009-12-02 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 386 ISSN: 1873-3476 ISO Abbreviation: Int J Pharm Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 172-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Calorimetry, Differential Scanning Chemistry, Pharmaceutical Delayed-Action Preparations Drug Carriers* Drug Compounding Freezing* Hypoglycemic Agents / chemistry* Insulin / chemistry* Kinetics Nitrogen / chemistry Porosity Silicon Dioxide / chemistry* Solubility Surface Properties Technology, Pharmaceutical / methods* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Drug Carriers; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 7631-86-9/Silicon Dioxide; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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