Document Detail


Release of preformed Ang II from myocytes mediates angiotensinogen and ET-1 gene overexpression in vivo via AT1 receptor.
MedLine Citation:
PMID:  12431448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IN CONCLUSION: (1) mechanical stress releases preformed angiotensin II from myocyte in vivo; (2) the AT1 blockade abolishes cardiac angiotensin II and endothelin-1 production with delayed recovery of myocardial contractility; whereas (3) the overexpression of insulin-like growth factor-I gene and the development of myocardial hypertrophy are not angiotensin II-mediated effects.
Authors:
Pietro Amedeo Modesti; Sra Zecchi-Orlandini; Simone Vanni; Gianluca Polidori; Iacopo Bertolozzi; Avio Maria Perna; Lucia Formigli; Ilaria Cecioni; Mirella Coppo; Maria Boddi; Gian Gastone Neri Serneri
Related Documents :
152168 - Cardiac metabolsim: its contributions to alcoholic heart disease and myocardial failure.
1951128 - Effect of digoxin on contractility and symptoms in infants with a large ventricular sep...
9724308 - Proinflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechan...
17938418 - Matters of the heart: the physiology of cardiac function and failure.
12391418 - New perspectives on catheter-based ablation of ventricular tachycardia complicating cha...
17362898 - Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfus...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  34     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-14     Completed Date:  2003-06-05     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1491-500     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin II / secretion*
Angiotensin Receptor Antagonists
Angiotensinogen / biosynthesis*,  genetics
Animals
Aortic Valve Stenosis / physiopathology
Cardiac Catheterization
Cytoplasm / chemistry
Disease Models, Animal
Endothelin-1 / biosynthesis*,  genetics
Gene Expression Regulation*
Heart / secretion*
Insulin-Like Growth Factor I / biosynthesis,  genetics
Microscopy, Confocal
Myocardium / cytology,  metabolism*
RNA, Messenger / biosynthesis,  genetics
Receptor, Angiotensin, Type 1
Receptors, Angiotensin / physiology*
Renin-Angiotensin System / physiology
Stress, Mechanical
Swine
Systole
Tetrazoles / pharmacology
Valine / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Endothelin-1; 0/RNA, Messenger; 0/Receptor, Angiotensin, Type 1; 0/Receptors, Angiotensin; 0/Tetrazoles; 11002-13-4/Angiotensinogen; 11128-99-7/Angiotensin II; 137862-53-4/valsartan; 67763-96-6/Insulin-Like Growth Factor I; HG18B9YRS7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gating of the late Na+ channel in normal and failing human myocardium.
Next Document:  Excitation-dependent intracellular Ca2+ waves at the border zone of the cryo-injured rat heart revea...