Document Detail

Release of preformed Ang II from myocytes mediates angiotensinogen and ET-1 gene overexpression in vivo via AT1 receptor.
MedLine Citation:
PMID:  12431448     Owner:  NLM     Status:  MEDLINE    
IN CONCLUSION: (1) mechanical stress releases preformed angiotensin II from myocyte in vivo; (2) the AT1 blockade abolishes cardiac angiotensin II and endothelin-1 production with delayed recovery of myocardial contractility; whereas (3) the overexpression of insulin-like growth factor-I gene and the development of myocardial hypertrophy are not angiotensin II-mediated effects.
Pietro Amedeo Modesti; Sra Zecchi-Orlandini; Simone Vanni; Gianluca Polidori; Iacopo Bertolozzi; Avio Maria Perna; Lucia Formigli; Ilaria Cecioni; Mirella Coppo; Maria Boddi; Gian Gastone Neri Serneri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  34     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-14     Completed Date:  2003-06-05     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1491-500     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / secretion*
Angiotensin Receptor Antagonists
Angiotensinogen / biosynthesis*,  genetics
Aortic Valve Stenosis / physiopathology
Cardiac Catheterization
Cytoplasm / chemistry
Disease Models, Animal
Endothelin-1 / biosynthesis*,  genetics
Gene Expression Regulation*
Heart / secretion*
Insulin-Like Growth Factor I / biosynthesis,  genetics
Microscopy, Confocal
Myocardium / cytology,  metabolism*
RNA, Messenger / biosynthesis,  genetics
Receptor, Angiotensin, Type 1
Receptors, Angiotensin / physiology*
Renin-Angiotensin System / physiology
Stress, Mechanical
Tetrazoles / pharmacology
Valine / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Endothelin-1; 0/RNA, Messenger; 0/Receptor, Angiotensin, Type 1; 0/Receptors, Angiotensin; 0/Tetrazoles; 11002-13-4/Angiotensinogen; 11128-99-7/Angiotensin II; 137862-53-4/valsartan; 67763-96-6/Insulin-Like Growth Factor I; HG18B9YRS7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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