| Release of peptide YY by fat in the proximal but not distal gut depends on an atropine-sensitive cholinergic pathway. | |
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MedLine Citation:
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PMID: 14687704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptide YY (PYY) is released when PYY cells in short term culture are exposed to fat suggesting that this peptide may be released by fat in the distal gut without neural stimulation. PYY is also released by fat in the proximal 1/2 of small intestine. To test the hypothesis that the release of PYY by fat in the proximal but not distal intestine may depend on an atropine-sensitive, cholinergic pathway, PYY levels were compared in four dogs equipped with duodenal and mid-intestinal fistulas when 60 mM oleate was perfused into either the proximal (between fistulas) or distal (beyond mid-intestinal fistula) 1/2 of gut at 2 ml/min for 120 min with intravenous administration of saline or atropine. We found that, when fat was confined to the proximal 1/2 of the intestine, PYY release was reduced following intravenous atropine when compared with saline (p<0.01). However, when fat was confined to the distal 1/2 of the intestine, PYY release was not affected by the intravenous atropine. We conclude that PYY release by fat in the proximal but not distal intestine depends on an atropine-sensitive, cholinergic pathway. |
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Authors:
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Henry C Lin; Ian L Taylor |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Regulatory peptides Volume: 117 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-22 Completed Date: 2004-08-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 73-6 Citation Subset: IM |
Affiliation:
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GI Motility Program and Section of Nutrition, Department of Medicine, Cedars-Sinai Medical Center, CSMC Burns and Allen Research Institute, Los Angeles, CA 90048, USA. henry.lin@cshs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects*,
secretion Animals Atropine / pharmacology* Cholinergic Fibers / metabolism* Digestive System Dogs Injections, Intravenous Intestinal Fistula Intestine, Small / cytology*, metabolism Oleic Acid / administration & dosage, pharmacology Peptide YY / blood, metabolism*, secretion Sodium Chloride / administration & dosage Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK 46459/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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106388-42-5/Peptide YY; 112-80-1/Oleic Acid; 51-55-8/Atropine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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