Document Detail

Release of motilin by oral and intravenous nutrients in man.
MedLine Citation:
PMID:  428820     Owner:  NLM     Status:  MEDLINE    
Motilin is a hormonal peptide found in the duodenum and jejunum which potently influences gastrointestinal tract motility. Its role in human physiology is not yet established. After a standard hospital lunch the plasma concentration of motilin showed a small, transient, but significant rise in 28 healthy subjects. Individual food components either stimulated (oral fat) or suppressed release (oral glucose). Plasma motilin levels were, in addition, altered to an equal extent by intravenous nutrients, with glucose and amino acids suppressing release, and intravenous fat causing a significant rise in plasma concentration. These results demonstrate a consistent response to food stimuli, whether oral or intravenous. The release mechanism appears to be complicated and after a balanced meal, containing food components which both stimulate and suppress release, there is only a small net change.
N D Christofides; S R Bloom; H S Besterman; T E Adrian; M A Ghatei
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  20     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Amino Acids / administration & dosage
Arginine / administration & dosage
Dietary Fats
Fat Emulsions, Intravenous
Gastrointestinal Hormones / secretion*
Glucose / administration & dosage
Infusions, Parenteral
Middle Aged
Motilin / blood,  secretion*
Reg. No./Substance:
0/Amino Acids; 0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Gastrointestinal Hormones; 50-99-7/Glucose; 52906-92-0/Motilin; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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