Document Detail


Release of lipoteichoic acid from Staphylococcus aureus by treatment with cefmetazole and other beta-lactam antibiotics.
MedLine Citation:
PMID:  6580289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of cefmetazole on the growth together with the release of cellular lipoteichoic acid from cefazolin-resistant strains of Staphylococcus aureus was compared with that of cefazolin, cefotiam, cefoxitin and cefuroxime. Bacteriolytic actions were measured by turbidity and bactericidal actions were followed by viable cell count. Release of cellular lipoteichoic acid was measured by the radioactivity in the supernatant of the cultures. Cefmetazole exerted more potent effects on the bacterial growth and induced more marked release of cellular lipoteichoic acid from resistant strains as compared with other beta-lactams.
Authors:
Y Utsui; S Ohya; Y Takenouchi; M Tajima; S Sugawara; K Deguchi; H Suginaka
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  36     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1380-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*,  toxicity
Cefmetazole
Cephamycins / pharmacology*,  toxicity
Glycerol / metabolism
Kinetics
Lipopolysaccharides*
Microbial Sensitivity Tests
Phosphatidic Acids / metabolism*
Staphylococcus aureus / drug effects,  metabolism*
Structure-Activity Relationship
Teichoic Acids / metabolism*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephamycins; 0/Lipopolysaccharides; 0/Phosphatidic Acids; 0/Teichoic Acids; 56-81-5/Glycerol; 56411-57-5/lipoteichoic acid; 56796-20-4/Cefmetazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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