Document Detail

Release of leukotriene C4 from guinea pig trachea.
MedLine Citation:
PMID:  6412317     Owner:  NLM     Status:  MEDLINE    
Immunological (ovalbumin) and non-immunological (calcium ionophore A23187) stimulation of guinea pig trachea induces a prolonged contraction that is enhanced by indomethacin (8.5 microM) and inhibited by nordihydroguaiaretic acid (50 microM) pretreatment of the tissue. The mediator released by the above stimuli was identified as leukotriene C4 by reverse-phase high performance liquid chromatography, and quantitated by bioassay. Indomethacin, and/or arachidonic acid (32.8 microM) did not enhance the release, whereas nordihydroguaiaretic acid reduced the contraction and release of LTC4. The results demonstrate the hitherto unproved capability of the large airways to synthesize leukotrienes and emphasize the importance of examining their role in asthma.
M H Saad; M A Wilson; J F Burka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  25     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  741-52     Citation Subset:  IM    
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MeSH Terms
Antioxidants / pharmacology
Calcimycin / pharmacology
Catechols / pharmacology
Chromatography, High Pressure Liquid
Guinea Pigs
Indomethacin / pharmacology
Muscle Contraction
Muscle, Smooth / drug effects,  physiology,  secretion*
Nordihydroguaiaretic Acid
Ovalbumin / pharmacology
SRS-A / secretion*
Trachea / drug effects,  physiology,  secretion*
Reg. No./Substance:
0/Antioxidants; 0/Catechols; 0/SRS-A; 500-38-9/Nordihydroguaiaretic Acid; 52665-69-7/Calcimycin; 53-86-1/Indomethacin; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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