Document Detail

Release of lamellar bodies from alveolar type 2 cells.
MedLine Citation:
PMID:  6247775     Owner:  NLM     Status:  MEDLINE    
The release of lamellar bodies from rat alveolar type 2 cells has been studied during a 12hr dark/12hr light cycle. A proportion of the type 2 cell population was ultrastructurally abnormal. The cellular changes formed a spectrum raninging from mild to severe, culminating in rupture of the cell and release of its contents into the alveolar air space. The majority of aberrant cells were observed in animals killed during the dark period. A holocrine secretory mechanism is suggested for the release of lamellar bodies containing the surface active phospholipids of the alveolar lining. The release of lamellar material by a process of exocytosis was also observed, but only rarely, in spite of the numerous lamellar bodies seen in each cell cross-section.
N F Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  35     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
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MeSH Terms
Inclusion Bodies / physiology*,  ultrastructure
Microscopy, Electron
Pulmonary Alveoli / physiology*,  ultrastructure

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