| Release of iron from ferritin by 6-hydroxydopamine under aerobic and anaerobic conditions. | |
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MedLine Citation:
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PMID: 2127409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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6-hydroxydopamine (6-OHDA) proved to be a very effective agent for iron release from ferritin. Iron release was enhanced in the presence of SOD, catalase and under anaerobic conditions. Ascorbic acid, a well known agent able to release iron from ferritin, increased the amount of released iron in more than an additive manner when used in combination with 6-OHDA. Similar to 6-OHDA, 6-hydroxydopa (Topa) and 1,2,4-benzenetriol were also able to release iron in large amounts; in contrast, catecholamines and other benzenediols were comparatively ineffective. |
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Authors:
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H N Lode; G Bruchelt; A G Rieth; D Niethammer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Free radical research communications Volume: 11 ISSN: 8755-0199 ISO Abbreviation: Free Radic. Res. Commun. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-04-15 Completed Date: 1991-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709453 Medline TA: Free Radic Res Commun Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 153-8 Citation Subset: IM |
Affiliation:
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Children's Hospital, Dept. Hematology and Oncology, University of Tuebingen, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerobiosis Anaerobiosis Ascorbic Acid / pharmacology Catalase / pharmacology Ferritins / metabolism* Hydroxydopamines / pharmacology* Iron / metabolism* Oxidopamine Superoxide Dismutase / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Hydroxydopamines; 1199-18-4/Oxidopamine; 50-81-7/Ascorbic Acid; 7439-89-6/Iron; 9007-73-2/Ferritins; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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