Document Detail

Release of iron from ferritin by 6-hydroxydopamine under aerobic and anaerobic conditions.
MedLine Citation:
PMID:  2127409     Owner:  NLM     Status:  MEDLINE    
6-hydroxydopamine (6-OHDA) proved to be a very effective agent for iron release from ferritin. Iron release was enhanced in the presence of SOD, catalase and under anaerobic conditions. Ascorbic acid, a well known agent able to release iron from ferritin, increased the amount of released iron in more than an additive manner when used in combination with 6-OHDA. Similar to 6-OHDA, 6-hydroxydopa (Topa) and 1,2,4-benzenetriol were also able to release iron in large amounts; in contrast, catecholamines and other benzenediols were comparatively ineffective.
H N Lode; G Bruchelt; A G Rieth; D Niethammer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Free radical research communications     Volume:  11     ISSN:  8755-0199     ISO Abbreviation:  Free Radic. Res. Commun.     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-15     Completed Date:  1991-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709453     Medline TA:  Free Radic Res Commun     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  153-8     Citation Subset:  IM    
Children's Hospital, Dept. Hematology and Oncology, University of Tuebingen, FRG.
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MeSH Terms
Ascorbic Acid / pharmacology
Catalase / pharmacology
Ferritins / metabolism*
Hydroxydopamines / pharmacology*
Iron / metabolism*
Superoxide Dismutase / pharmacology
Reg. No./Substance:
0/Hydroxydopamines; 1199-18-4/Oxidopamine; 50-81-7/Ascorbic Acid; 7439-89-6/Iron; 9007-73-2/Ferritins; EC; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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