Document Detail

Release of folic acid in mesoporous NFM-1 silica.
MedLine Citation:
PMID:  21137944     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Mesoporous NFM-1 silica with folic acid as template was prepared taking advantage of the supramolecular self-assembly of pterin groups and their abilities to form hexagonal liquid crystal phases. NFM-1 materials with the varied morphologies such as fiber, chiral twisting long-rod, gyroid, and amorphous particles were prepared by varying the amount of the co-structure directing agent, stirring speed and changing pH value of the synthesis. The release kinetics of NFM-1 samples with different morphologies were studied in phosphate buffer with pH = 7.4 in 37 degrees C under stirring. All the release kinetic curves are fitted by the power law and Higuchi equations. The fitting of the power law equation was separately done as for the released amount up to 60% or 100%. The materials show slow, long-term and sustained release of folic acid from mesoporous NFM-1 silica, which establishes a new foundation for the potential application in drug delivery and bioimaging.
Chunfang Zhou; Alfonso E Garcia-Bennett
Related Documents :
2892224 - Biochemical aspects of dysphoria: case study for hypothesis generation.
17684524 - Direct and indirect cellular effects of aspartame on the brain.
19191004 - Brain dysfunction in phenylketonuria: is phenylalanine toxicity the only possible cause?
14519944 - Effect of the spinal drug tramadol on the fatty acid compositions of rabbit spinal cord...
4906004 - Glycine inhibition of asparaginase.
24557724 - Inhibition of lettuce seed germination and seedling growth by antimetabolites of nuclei...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  10     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7398-401     Citation Subset:  -    
Nanologica AB, Drottning Kristinas väg 45, SE-114 28 Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrical nanowelding and bottom-up nano-construction together using nanoscale solder.
Next Document:  Quaternized chitosan (QCS) nanoparticles as a novel delivery system for ammonium glycyrrhizinate.