Document Detail


Release of essential fatty acids from the rat mesenteric vascular bed perfused in vitro: modulation by zinc.
MedLine Citation:
PMID:  2383803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rat mesenteric vascular bed releases prostaglandins when perfused in vitro. The present study evaluated the effect of perfusion of the rat mesenteric vascular bed in vitro with a buffer containing 0, 3, 6, or 9 nM of added zinc on the release of essential fatty acids over a 150-min period. Long chain fatty acids in the mesenteric lipids and in total lipid of the perfusion effluent were assayed by gas liquid chromatography. The presence of 6 nM zinc in the perfusing buffer almost completely prevented the change in 16-22 carbon long chain fatty acids in the mesenteric phospholipids and decreased the release of free fatty acids in comparison to that occurring in the absence of additional zinc. The results suggest that physiological amounts of zinc in the perfusion medium reduce the release of essential fatty acid from rat mesenteric lipids.
Authors:
S C Cunnane; B A Nassar
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  68     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  903-7     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ont., Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids, Essential / metabolism*
Male
Mesentery / metabolism*
Perfusion
Proteins / metabolism
Rats
Rats, Inbred Strains
Triglycerides / metabolism
Zinc / pharmacology*
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Proteins; 0/Triglycerides; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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