Document Detail

Release and depletion of substance P by capsaicin in substantia gelatinosa studied with the antibody microprobe technique and immunohistochemistry.
MedLine Citation:
PMID:  1281914     Owner:  NLM     Status:  MEDLINE    
Using an antibody microprobe technique, we have detected substance P release from the region of the substantia gelatinosa of the cat during the first, but not the second, 30 min of topical application of capsaicin (1-3%) to the tibial nerve. Immunohistochemical analysis also showed that substance P-like immunoreactivity was markedly reduced in the superficial layer of the dorsal horn 30 min after application of capsaicin. These results indicate that substance P is released and then depleted from primary afferent central terminals following acute application of capsaicin to the peripheral sensory nerve.
Z Q Zhao; H Q Yang; K M Zhang; X X Zhuang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropeptides     Volume:  23     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-28     Completed Date:  1993-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  161-7     Citation Subset:  IM    
Shanghai Brain Research Institute, Chinese Academy of Sciences, Shanghai.
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MeSH Terms
Afferent Pathways / drug effects,  metabolism
Antibodies / immunology*
Capsaicin / pharmacology*
Nerve Endings / drug effects*,  metabolism
Substance P / metabolism*
Substantia Gelatinosa / drug effects*,  metabolism
Video Recording
Reg. No./Substance:
0/Antibodies; 33507-63-0/Substance P; 404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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