Document Detail

Release of cholecystokinin in man: correlation of blood levels with gallbladder contraction.
MedLine Citation:
PMID:  7271349     Owner:  NLM     Status:  MEDLINE    
Although it is generally assumed that release of cholecystokinin (CCK) is the chief mechanism by which a fatty meal causes contraction of the gallbladder, measured release of CCK and gallbladder contraction have never been correlated. We have achieved this correlation in eight adult male volunteers, by means of a specific radioimmunoassay for CCK and by ultrasonographic imaging of the gallbladder. This study validates our CCK radioimmunoassay and correlates measured concentrations of CCK with changes in gallbladder size measured by ultrasonographic examination. Basal concentrations of CCK (82.6 +/- 10.4 pg/ml) rose significantly to a maximum of 411.1 +/- 79.9 pg/ml at 16 minutes after intraduodenal instillation of medium-chain triglyceride (Lipomul). Mean basal volume of the gallbladder was 34.6 cm3; maximum reduction of gallbladder volume (to one-third of original) was achieved at 18 minutes. Elevated CCK concentrations began to fall toward basal, and the gallbladder began to refill at 25 minutes. Results obtained after oral ingestion of Lipomul provide similar results. Linear regression analysis demonstrated excellent correlation between concentrations of CCK and gallbladder size during both contraction and relaxation phases. Future study of this correlation may be useful in patients with manifest dysfunction of the gallbladder, as well as in individuals known to be at risk of gallbladder disease.
I Wiener; K Inoue; C J Fagan; P Lilja; L C Watson; J C Thompson
Related Documents :
23326709 - Marathon runner with acute hyponatremia: a neurological disorder.
3678179 - Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, po...
7701769 - The effect of reversible left recurrent laryngeal neuropathy on the metabolic cost of l...
22550549 - A novel expression of exercise induced pulmonary hypertension in human immunodeficiency...
11453479 - Results of intradermal tests in horses without atopy and horses with atopic dermatitis ...
1524299 - Influence of furosemide on hemodynamic responses during exercise in horses.
11781859 - Treadmill exercise testing with increasing inclination as exercise protocol for wheelch...
17117349 - History and principles of exercise-based therapy: how they inform our current treatment.
22342849 - Effect of marathon run and air travel on pre- and post-run soluble d-dimer, micropartic...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  194     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cholecystokinin / blood,  secretion*
Corn Oil
Gallbladder / physiology*
Intestinal Mucosa / secretion
Middle Aged
Muscle Contraction
Zea mays
Grant Support
Reg. No./Substance:
0/Oils; 8001-30-7/Corn Oil; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pancreatic duct drainage in 100 patients with chronic pancreatitis.
Next Document:  Immunological properties of seminal vesicle fluid.