Document Detail

Release of chemotactic factors by veins during preparation for arterial bypass.
MedLine Citation:
PMID:  2181974     Owner:  NLM     Status:  MEDLINE    
With the use of arterial bypass release neutrophil chemotactic factors, saphenous veins were removed from dogs by means of standard surgical technique and were distended to a pressure of 200 mm Hg for 15 minutes with cold (4 degrees C) plasmalyte solution. Veins cannulated in situ and flushed with cold (4 degrees C) plasmalyte solution served as negative controls. Experimental and control flush solutions were assayed for the presence of neutrophil chemotactic factors with the use of modified Boyden chambers. Chemotactic activity from the distended vein grafts was 2.2 to 7.2 times the control value. Biologic chemotactic activity was demonstrated as well. These results suggest a role for the vein graft itself in the recruitment of neutrophils to implanted veins by releasing chemoattractants.
S T Ruby; M E Allam; M A Gallo; S Barth; S A Elgebaly
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  125     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-10     Completed Date:  1990-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-4     Citation Subset:  AIM; IM    
Department of Surgery, Connecticut Health Center, Farmington 06032.
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MeSH Terms
Chemotactic Factors / pharmacology,  secretion*
Chemotaxis, Leukocyte
Neutrophils / physiology
Saphenous Vein / secretion,  transplantation*
Skin / pathology
Reg. No./Substance:
0/Chemotactic Factors; 0/Interleukin-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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