Document Detail

Release of cytokines/chemokines and cell death in UVB-irradiated human keratinocytes, HaCaT.
MedLine Citation:
PMID:  18782623     Owner:  NLM     Status:  MEDLINE    
Ultraviolet (UV) B can lead to inflammatory responses such as sunburn, which involves the production of various inflammatory cytokines and chemokines, and the induction of cell death. Keratinocytes in the skin has one of the highest risks of exposure to UV. However, the detailed mechanisms underlying UVB irradiation-induced inflammation and cell death are not well known. Thus, we investigated the effect of UVB irradiation on the production of various cytokines/chemokines and the induction of cell death in UVB-irradiated human keratinocytes (HaCaT cells). We evaluated 11 cytokines/chemokines in cell culture supernatants from HaCaT cells exposed to 0-400 mJ/cm(2) UVB irradiation. UVB at a dose 400 mJ/cm(2) induced the release of various cytokines; interleukin (IL)-1beta, IL-6, IL-8, interferon (IFN)-gamma, granulocyte-colony stimulating factor (G-CSF), macrophage inflammatory protein (MIP)-1beta, and tumor necrosis factor (TNF)-alpha. These results suggest that UVB irradiation-induced the release of several cytokines/chemokines and led to cell death in human keratinocytes. UV exposure may be associated with multiple physiological events in the human skin.
Masakazu Yoshizumi; Tadashi Nakamura; Masahiko Kato; Taisei Ishioka; Kunihisa Kozawa; Kaori Wakamatsu; Hirokazu Kimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-20
Journal Detail:
Title:  Cell biology international     Volume:  32     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1405-11     Citation Subset:  IM    
Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan.
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MeSH Terms
Cell Death / immunology,  radiation effects
Cell Line
Chemokine CCL4 / immunology,  secretion
Chemokines / immunology*,  secretion
Cytokines / immunology*,  secretion
Granulocyte Colony-Stimulating Factor / immunology,  secretion
Inflammation / immunology,  physiopathology
Interferon-gamma / immunology,  secretion
Interleukins / immunology,  secretion
Keratinocytes / immunology*,  radiation effects*,  secretion
Radiation Dosage
Tumor Necrosis Factor-alpha / immunology,  secretion
Ultraviolet Rays / adverse effects*
Reg. No./Substance:
0/Chemokine CCL4; 0/Chemokines; 0/Cytokines; 0/Interleukins; 0/Tumor Necrosis Factor-alpha; 143011-72-7/Granulocyte Colony-Stimulating Factor; 82115-62-6/Interferon-gamma

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