Document Detail

Release by electrical stimulation of endogenous glutamate, gamma-aminobutyric acid, and other amino acids from slices of the rat medulla oblongata.
MedLine Citation:
PMID:  2562808     Owner:  NLM     Status:  MEDLINE    
Evidence was obtained for the release of amino acids by electrical stimulation of slices of regions of the rat medulla oblongata: rostral ventrolateral, caudal ventrolateral and caudal dorsomedial. There was a Ca2+-dependent, tetrodotoxin-sensitive increase in the efflux of aspartate, glutamate, gamma-aminobutyric acid (GABA), glycine, and beta-alanine in all regions examined. There were distinct regional differences in the relative amounts of amino acids released. These results provide evidence for the possible neurotransmitter role of aspartate, glutamate, GABA, glycine, and beta-alanine in these regions of the rat medulla oblongata.
M Kihara; Y Misu; T Kubo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  52     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-01-25     Completed Date:  1989-01-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Amino Acids / metabolism*
Calcium / metabolism
Chromatography, High Pressure Liquid
Electric Stimulation
Glutamates / metabolism*
Glutamic Acid
Medulla Oblongata / metabolism*
Rats, Inbred Strains
Tetrodotoxin / pharmacology
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 4368-28-9/Tetrodotoxin; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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