Document Detail

Release of bicarbonate from damaged and restituted gastric mucosa in the cat.
MedLine Citation:
PMID:  8514064     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gastric mucosal damage leads to luminal alkalinization, but its dependence on mucosal blood flow and acid secretory state of the mucosa is not known. This study examined release of bicarbonate to the gastric lumen and mucosal blood flow in cats after mucosal damage caused by 2 mol/L NaCl and during 90 minutes of epithelial restitution. METHODS: Bicarbonate was calculated from measurements of pH and PCO2 in the luminal perfusate. Mucosal blood flow was measured with microspheres. RESULTS: Luminal bicarbonate increased more than twofold after damage in pharmacologically nontreated, pentagastrin-treated, and omeprazole-treated animals (P < 0.001). Luminal bicarbonate thereafter decreased completely to pre-damage level in pentagastrin-treated, partly in nontreated, but remained elevated in omeprazole-treated animals. Mucosal blood flow increased about 100% 15 minutes after damage (P < 0.001), irrespective of secretory state. Bicarbonate availability (arterial [HCO(3-)] x mucosal blood flow) was significantly related to luminal release of bicarbonate from the newly damaged (P < 0.01) but not from the restituted mucosa. CONCLUSIONS: (1) From the newly damaged mucosa, the luminal release of bicarbonate is related to availability of blood-borne bicarbonate. (2) From acid-stimulated restituted mucosa, the bicarbonate produced by the parietal cells is not released to the lumen, but either consumed within the mucosa by back-diffusing H+ or distributed to the systemic circulation.
K Guttu; B Røsok; K Svanes; J E Grønbech
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  105     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-07-22     Completed Date:  1993-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  74-83     Citation Subset:  AIM; IM    
Department of Surgery, University of Bergen, Norway.
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MeSH Terms
Bicarbonates / metabolism*
Carbon Dioxide / blood
Gastric Acidity Determination
Gastric Mucosa / blood supply,  metabolism*,  pathology*
Regional Blood Flow
Saline Solution, Hypertonic / toxicity
Reg. No./Substance:
0/Bicarbonates; 0/Saline Solution, Hypertonic; 124-38-9/Carbon Dioxide

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