Document Detail

Release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream.
MedLine Citation:
PMID:  7308554     Owner:  NLM     Status:  MEDLINE    
Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate (betamethasone 17-valerate, 0.1%) cream. Blanching assessment as undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating hat the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.
A D Magnus; J M Haigh; I Kanfer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatologica     Volume:  163     ISSN:  0011-9075     ISO Abbreviation:  Dermatologica     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0211607     Medline TA:  Dermatologica     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  331-7     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Betamethasone* / analogs & derivatives
Betamethasone 17-Valerate* / administration & dosage
Biological Assay
Chemical Phenomena
Drug Stability
Reg. No./Substance:
0/Vehicles; 2152-44-5/Betamethasone 17-Valerate; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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