Document Detail


Release of avian neurotensin in response to intraluminal contents in the duodenum of chickens.
MedLine Citation:
PMID:  23300309     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Peripheral and hepatic-portal plasma levels of neurotensin (NT) in fed and fasted chickens were determined using RIA. Portal levels of NT(1-13) (fed = 61.3 ± 3.9 fmol/mL; fasted = 44.5 ± 3.9 fmol/mL) were significantly higher than peripheral levels (fed = 8.2 ± 3.3 fmol/mL; fasted = 7.8 ± 3.0 fmol/mL) collected from the wing vein, indicating that some NT is metabolized in the liver. Portal plasma levels of NT collected from fed birds were also significantly higher than portal plasma levels of NT collected from fasted birds. Neurotensin, as identified by HPLC, exhibited a 2-fold increase in plasma extracts following perfusion of the proximal ileum with a 10-mg sample of oleic acid, as compared with control samples of plasma collected before oleic acid perfusion. In whole-animal studies, the injection of a micellar solution of oleic acid into isolated segments of the duodenum resulted in elevated plasma immunoreactive NT in blood collected from the pancreaticoduodenal vein. Injection of a 1,000 mOsm sodium chloride solution had a slightly lesser and delayed effect compared with oleic acid, but a greater effect than 0.1 N hydrochloric acid in isotonic saline solution. Injection of an amino acid solution (10% Travasol), 300 mOsm glucose solution, or pure corn oil had no effect. These results demonstrate that intraduodenal oleic acid is a potent stimulus for the release of NT from the duodenum into the hepatic-portal circulation of chickens.
Authors:
Teresa F Degolier; Robert E Carraway; Gary E Duke
Related Documents :
23510799 - Neomycin-loaded poly(styrene sulfonic acid-co-maleic acid) (pssa-ma)/polyvinyl alcohol ...
24292439 - Highly stereoselective biosynthesis of (r)-α-hydroxy carboxylic acids through rational...
24736679 - Impact of stearic acid and oleic acid on hemostatic factors in the context of controlle...
24147979 - Metabolic flux between unsaturated and saturated fatty acids is controlled by the faba:...
24099559 - Two-step method of enzymatic synthesis of starch laurate in ionic liquids.
23401109 - Effect of nutrient-based fertilisers of olive trees on olive oil quality.
8245689 - The effect of chemical modification of basic amino acid residues on the activation and ...
3291599 - Splanchnic exchange of amino acids after amino acid ingestion in patients with chronic ...
10627499 - Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient i...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  92     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-23     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Bethel University, St. Paul, MN 55112;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of the diving reflex in response to nonterminal submersion of White Pekin ducks in water-...
Next Document:  Screening for cytotoxic activity of ovotransferrin and its enzyme hydrolysates.