Document Detail

Release of atrial natriuretic peptide by atrial distension.
MedLine Citation:
PMID:  2931169     Owner:  NLM     Status:  MEDLINE    
A heterologous radioimmunoassay was used to measure the concentration of immunoreactive atrial natriuretic peptide (iANP) in plasma from the femoral artery of eight chloralose anaesthetized dogs. Mitral obstruction which increased left atrial pressure by 11 cmH2O increased plasma iANP from 97 +/- 10.3 (mean +/- SE) to 135 +/- 14.3 pg/mL. Pulmonary vein distension increased heart rate but did not increase plasma iANP. Bilateral cervical vagotomy and administration of atenolol (2 mg/kg) did not prevent the increase in iANP with mitral obstruction. Samples of blood from the coronary sinus had plasma iANP significantly higher than simultaneous samples from the femoral artery confirming the cardiac origin of the iANP. Release of iANP depends on direct stretch of the atrium rather than on a reflex involving left atrial receptors.
J R Ledsome; N Wilson; C A Courneya; A J Rankin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  63     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-11-04     Completed Date:  1985-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  739-42     Citation Subset:  IM    
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MeSH Terms
Atrial Function
Atrial Natriuretic Factor / blood,  secretion*
Electric Stimulation
Heart / anatomy & histology,  physiology*
Heart Atria / anatomy & histology
Myocardium / metabolism*
Tissue Extracts / pharmacology
Reg. No./Substance:
0/Tissue Extracts; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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